Pathological and histomorphometric study of comparative gastric ulcer induced by indomethacin, aspirin, and ethanol in rats

This study aimed comparison the gastric ulcer induced by indomethacin, aspirin, and ethanol on level of pathological changes, ulcers surface area, index. Forty rats were divided into 4 groups: control group received normal saline, remaining groups, Indomethacin 40 mg/kg, Aspirin group100 80% 5 ml/kg, all doses orally administrated one time. The result revealed had largest whereas indomethacin a significantly lowest index after 3 hrs., no significant differences among groups 24 hrs. Gastric in hours, while approximate treated Histopathological changes erosions or with necrosis, hemorrhage, inflammation, as well complete exfoliation mucosa reaching muscularis PAS/AB stain showed intense, slight, moderate mucus reactivity respectively, decreased COX-2 expression increased aspirin except groups. We conclude that area was severer severe decline production modest rise COX2 expression, which stronger weak